Structure, Target, Reaction Mechanism and Analgesic Activity of Novel alpha-Conopetide Eb1.6

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  Alpha-conopeptides belongs to a superfamily of conotoxins and specifically targets nAChR.Some peptides that inhibit nAChR alpha9alpha10,alpha3beta2 exhibits potent analgesic activities in rat neuropathic pain model.Recently,a novel alpha-conopeptide Eb1.6(CCSNPACMLKNPNLC-NH2,the disulfide bond is “1-3,2-4”)was cloned from C.eberneus in South China Sea.The rat CCI and PNL model demonstrated that Eb1.6 exhibited potent analgesic activity at nmol/kg level(0.25~25 μg/kg,i.m.),and 1000 times higher than the co-administration of morphine(5 mg/kg)and gabapendin(100 mg/kg).In addition,Eb1.6 is active to diabetes pain and some acute pain models(hot plate).
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