Ethnopharmacological relevance: Neuropathic pain was regarded as a main form of chronic pain condition that remains difficult to treat.The transient receptor potential vanilloid channel 1(TRPV1),which plays a crucial role in chronic sciatic nerve constriction injury(CCI)model induced neuropathic pain.In China,Ruxiang(Frankincense)and Myrrh are often used together on clinic in order to obtain a synergistic effect for relieving pain(e.g.,CCI).However,the evaluation of the effects and mechanisms keep unclear.