progranulin相关论文
Progranulin protects against intervertebral disc degeneration through interacting with Akt and NF-κB
Objective We previously reported that progranulin (PGRN) was an osteoarthritis (OA)-associated growth factor (Annals of ......
Angiogenin prevents progranulin A9D mutation induced neuronallike cell apoptosis through cleaving tR
Gene defects have been recognized as prominent factors in the etiology and pathogenesis of neurodegenerations.Among 60 n......
Down-regulation of progranulin improve learning and memory in mouse model of fragile X syndrome thro
OBJECTIVE To exhibit the role of PGRN in fragile X syndrome(FXS)cognition disability development.METHODS Expression of P......
Down-regulation of progranulin improve learning and memory in a mice model of fragile x syndrome thr
Fragile X syndrome(FXS)is the most common inherited cause of autism and intellectual disability only after Downs syndrom......
Atsttrin reduces lipopolysaccharide-induced neuroinflammation by inhibiting the nuclear factor kappa
Progranulin is closely related to neuronal survival in a neuroinflammatory mouse model and attenuates inflammatory react......
颗粒蛋白前体是一个多功能生长因子，其对调节和维护机体正常组织的发展、增殖、再生及防御稳态发挥重要作用。颗粒蛋白前体与感染、......
Progranulin(PGRN)has recently emerged as a key player in a subset of frontotemporal dementias(FTD).Numerous mutations in......
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Background Progranulin is a newly discovered 88-kDa glycoprotein originally purified from the highly tumorigenic mouse t......
目的探讨血清脂肪因子颗粒蛋白前体（Progranulin）和IL-6水平与多囊卵巢综合征（PCOS）患者胰岛素抵抗（IR）的相关性。方法选取2013年8月—20......
目的通过观察颗粒蛋白前体（progranulin,PGRN）和Ki-67在胃癌及癌旁组织中的水平及相关性,探讨PGRN与胃癌形成、发展的关系及意义。方......
目的探讨血清颗粒蛋白前体(progranulin,PGRN)在原发性肝细胞癌(hepatocellular carcinoma,HCC)诊断中的潜在应用价值。方法首先从......
为探讨颗粒蛋白前体(progranulin,PGRN)小干扰RNA对提高小鼠切创损伤创面愈合质量的作用,通过选取33只健康雄性BALB/c小鼠,制作小......
目的探讨妊娠期糖尿病患者血清颗粒蛋白前体水平的变化及其与胰岛素抵抗的相关性。方法选取2017年2月至2018年2月在该院产前检查的......
目的研究颗粒蛋白前体（PGRN）在肥胖PCOS大鼠卵巢中的表达情况,初步探讨PGRN在PCOS发病中的作用。方法选择SPF级23日龄SD雌性大鼠38只......
目的:研究慢性阻塞性肺疾病急性加重(AECOPD)患者在治疗前后血清颗粒蛋白前体(PGRN)的水平变化及对病情评估的临床意义。方法:将AE......
目的：探讨一种简单、有效、快捷的方法来提取颗粒蛋白前体（PGRN）基因敲除（PGRN-/-）小鼠的DNA以及基因的鉴定方法,同时建立鸡Ⅱ型胶原诱......
Atsttrin reduces lipopolysaccharide-induced neuroinflammation by inhibiting the nuclear factor kappa
Progranulin is closely related to neuronal survival in a neuroinflammatory mouse model and attenuates inflammatory react......
GP88 (Progranulin) Confers Fulvestrant (Faslodex, ICI 182,780) Resistance to Human Breast Cancer Cel
The 88 kDa glycoprotein known as GP88, Progranulin or PC cell derived growth factor is an autocrine growth factor with a......
Aim: To study serum progranulin (PGRN) level in children with obesity and its relationship to inflamamatory markers and ......
骨关节炎是关节炎中的一种,是一种常见的慢性退化性疾病,以关节软骨破坏,关节软骨基质丢失,关节滑膜炎症产生,关节软骨下骨硬化以......
股骨头坏死(Osteonecrosis of femoral head,ONFH)是骨关节系统的常见病、多发病,病变早期患者以髋关节疼痛及活动障碍为主要临床......
据美国BIOCOMPARE科技新闻网（2006／7／19）报道，英属哥伦比亚大学及曼彻斯特大学的研究人员发现，前颗粒蛋白（Progranulin）基因突变会造成额颞......
AIM:To understand the neuroprotective mechanism of human umbilical cord blood-derived mesenchymal stem cells(hUCB-MSCs) ......
宫颈癌是女性最常见的恶性肿瘤之一,尽管已有人乳头瘤病毒(Human papillomavirus,HPV)疫苗等预防措施,但仍然严重威胁着女性健康,......
宫颈癌是女性生殖系统最常见的恶性肿瘤之一。据统计数据显示,宫颈癌是女性第四常见的肿瘤,并已成为15-44岁女性中仅次于乳腺癌的......
目的本研究旨在检测生长因子progranulin在不同分子分型的乳腺癌组织中的表达及其临床意义,并与血管生成因子VEGF和CD105的表达量......
[研究背景]大面积骨缺损的治疗一直是一个困扰临床医生的技术难题。除骨移植外,生长因子,生物材料及相关干细胞研究的组织工程学为......
类风湿性关节炎是一种慢性系统性炎性失调,自身免疫在其慢性和进行性方面发挥着关键作用,因此类风湿性关节炎被认为是一种全身性自......
骨性关节炎,作为一种常见的关节退行性疾病,具有如下几个主要特点：关节软骨细胞的分化及成熟,细胞外基质的进行性降解,关节软骨成分......
