Aberrant Expression of Oct-4 in Human Breast Cancer

来源 :2011第四届世界癌症大会 | 被引量 : 0次 | 上传用户：lafang123456

【摘要】

：

【作者】

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Yogi Misra Dabiao Li Guo Zhang David Krag Donald Weaver Joseph Tessitore Feng-Qi Zhao

【机构】

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Laboratory of Lactation Physiology, Department of Animal Science, University of Vermont, USA

【出处】

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2011第四届世界癌症大会

【发表日期】

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2011年3期

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　　The POU domain transcription factor Oct-4 (POU5F1 or Oct-3) is a member of the homeobox gene family and is specifically expressed in totipotent mouse and human embryonic stem (ES) and germ cells.It is considered to be a gatekeeper in the early steps of mammalian embryogenesis because of its pivotal role in the regulation and maintenance of pluripotency and self-renewal of ES cells.Expression of Oct-4 is downregulated when embryonic stem cells are triggered to differentiate and is lost in normal somatic cells of differentiated tissues.

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Aberrant Expression of Oct-4 in Human Breast Cancer

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