【摘 要】
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Photodynamic cancer therapy(PDT)which has the advantages of being non-invasive and causing minimal adverse effects,holds great promise for cancer therapy[1].However,PDT-induced further hypoxia could c
【机 构】
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MOE Key Laboratory of Bioinorganic and Synthetic Chemistry,School of Chemistry,Sun Yat-Sen Universit
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Photodynamic cancer therapy(PDT)which has the advantages of being non-invasive and causing minimal adverse effects,holds great promise for cancer therapy[1].However,PDT-induced further hypoxia could compromise its therapeutic efficacy and even promote cancer recurrence and progression.We have designed and synthesized rhenium(I)complexes modified by CAIX inhibitors(ReCA)as cancer-specific PDT agents with hypoxic modulation capability[2].ReCA showed more effective cellular uptake and higher photocytotoxicity to aggressive MDA-MB-231 cancer cells that over-express CAIX on membranes than the reference Re compounds without CAIXi modification.Under the same condition,the proliferation of cancerous MCF-7 or normal MCF-10A cells that poorly expressed CAIX were not inhibited by ReCA.The combination of CA-IX inhibition and metal complexes not only facilitate their tumor accumulation but also regulate the CAIX-related pathway and hypoxia microenvironment accompanied with PDT,eventually has a synergistic anti-cancer effect.
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