Prognosis and Pathologic Characteristics of Post-radical-radiation Surgery in Rare Pathological Type

来源 :江西省第十四次妇产科学学术会议 | 被引量 : 0次 | 上传用户:zhaojiagu
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  Objective: To assess the prognosis of rare pathological type advanced cervical carcinoma with post-radical-radiation surgery.To compare the clinic value between further surgery treatment group and non-surgery group after radical radiation therapy.Method: From Jan 2002 to July 2010 there were 68 patients of advanced stage cervical carcinoma analysised in Matemal and Child Health Hospital of Jiangxi Province retrospectively.All patients were confirmed by histopathology before treatment, and clinical staging is based on updated 2009 FIGO staging, all patients were Ib2 (local advanced) and more severe.There were 36 patients (29 adenocarcinoma, 6 adenosquamous carcinoma and 1 undifferentiated carcinoma) classified into observation group that treated radical radiation therapy+surgery (total hysterectomy + bilateral salpingo-oophorectomy);other 32 patients (26 adenocarcinoma, 5 adenosquamous carcinoma and 1 undifferentiated carcinoma) classified into control group that treated radical radiation therapy no further surgery.The radical radiation therapy included external-beam radiation and intracavitary therapy, standard point A dose added up to 85Gy (These doses are recommended for most patients based on summation of conventional external-beam fractionation and low-dose rate 40~70 cGy/h brachytherapy equivalents), and 45~55Gy was given to point B.All of the patients were followed up.The average follow-up time was 65.6 months and compare the survival rate between two groups and analyzed whether there was residual lesion, metastasis, lymph vascular space invasion(LVSI) in observation group.Results: In observation group there were positive found in 15 patients.The positive rate was 41.7% (15/36), in which 9 cases with LVSI and residual foci;4 cases with uterus invasion;1 case only residual foci.Both of the two groups were followed up, and the average follow-up time was 65.6 months (rang 36~136 months).In observation group there are 25 cases survived up to now, the average survival time was 66.6 months (rang 36~136 months).11 patients died whos average survival time was 10.4 months (rang 2~37 months).In control group there are 22 cases survived up to now (July 2013), the average survival time was 64.4 months (rang 36~136 months).10 patients died whos average survival time was 10.3 months (rang 3~28 months).3 cases experienced serious complication in observation group, and 2 cases in control group.There was no significant difference of survival time between the two groups.Conclusion: Due to low efficacy results, post-radical-radiation surgery is not a feasible treatment regimen for rare pathological type advanced cervical carcinoma.
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