【摘 要】
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Karyopherins also called Importins, including alpha-and beta-type, are important transport proteins in eukaryotic cells that carry cargoes across nuclear pore complexes into or out of nucleus.Karyophe
【机 构】
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College of life science, Huaibei normal university, Anhui, Huaibei, 235000
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Karyopherins also called Importins, including alpha-and beta-type, are important transport proteins in eukaryotic cells that carry cargoes across nuclear pore complexes into or out of nucleus.Karyopherin alphas (KPNAs) cannot carry cargoes across nuclear pore complexes (NPCs) by themselves but they can act as receptors attaching cargoes to Karyopherin beta 1 (KPNB 1) and forming trimers which can across NPCs and finally release cargoes in nucleoplasm.Karyopherin betas (KPNBs) include Importin betas, Exportins and Transportins.Importin betas transport cargoes into nucleus and only Karyopherin beta 1 (KPNB 1) can recognize KPNAs to form complexes.Exportins transport cargoes out nucleus while transportins transport cargoes either into or out nucleus.
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