Cardiometabolic diseases comprise a spectrum of interconnected pathological alterations in metabolic organs and in the cardiovascular system that occur alone or simultaneously.An ambiguous understanding of the latent pathogenesis of cardiometabolic diseases might be responsible for their consistently high morbidity and mortality.Innate immunity, an evolutionarily ancient and universal response of the host to defend against infection and injury,underlies inflammatory responses that are triggered by innate immune molecular cascades.