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  5. Underivatized amino acids analysis based on ultra performance liquid chromatography coupled to Q-TOF

Underivatized amino acids analysis based on ultra performance liquid chromatography coupled to Q-TOF

来源 :DaLian Internationall Symposia and Exhibition on Chromatogra | 被引量 : 0次 | 上传用户：kathrynde
【摘 要】
：
Amino acids play an important role in the metabolism of the human organism.Abnormal levels of amino acids suggest that certain metabolism pathway has been disrupted.For instance, phenyl ketonuria will
【作 者】
：
Jing Chen Peiyuan Yin XinLu Guowang Xu 
【机 构】
：
National Chromatographic Research and Analysis Center, Institute of Chemical Physics, the Chinese Ac
【出 处】
：
DaLian Internationall Symposia and Exhibition on Chromatogra
【发表日期】
：
2007年12期
【关键词】
：
Amino Acid UPLC-MS hydrophilic interaction chromatography 
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　　Amino acids play an important role in the metabolism of the human organism.Abnormal levels of amino acids suggest that certain metabolism pathway has been disrupted.For instance, phenyl ketonuria will probably appear when phenylalanine can not be transit to tyrosine.Amino acids are small molecule with polarity and not or only poorly separated due to weak retention on reversed-phase HPLC/UPLC column.Traditional LC-MS method for amino acids analysis is to enhance retention of amino acids on C 18 column by pre-column derivatization or adding ion-paring agent.
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