Scavenger receptor-targeted dextran sulfate-methotrexate prodrug for treatment of collagen-induced a

来源 :Fourth Symposium on Innovative Polymers for Controlled Deliv | 被引量 : 0次 | 上传用户:zxc286929269
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
  Rheumatoid arthritis (RA) is a chronic systemic autoimmune disorder characterized by synovitis and articular cartilage damage.In the development of RA,the activated macrophages definitely play a pivotal role in persistence of inflammation and destruction of affected joints[1].
其他文献
Advances in nanotechnology-based medicine offer excellent opportunity to design nanosized entities comprising pharmaceutical agents that can potentially track undruggable diseases (typically by small
One of the biggest barriers for the further application of non-viral gene vectors is their unsatisfied gene transfection efficiency[1].Recent reports showed that the morphology of gene vectors influen
In human body,Reactive Oxygen Species (ROS) in inflammatory tissues are produced to play key roles in some physiological processes such as cell signalling and apoptosis,native immunity,and so forth[1]
A notable obstacle to develop peptide drugs is that native peptides often lack the capability to cross cell membranes and reach their intracellular targets.
Mesoporous silica nanoparticles (MSNs),due to their excellent in vitro and in vivo biocompatibility and high drug loading capacity,have been used for drug delivery.In our previous work,a drug-loaded s
Amphiphilic molecule generally contains a hydrophilic part and a hydrophobic part,which are linked by covalent bonding[1].The special amphiphilic feature drives the molecules to self-assemble into wel
Chitosan (CS) has been adopted to have great potentials in pharmaceutical science due to its outstanding properties of biocompatibility,biodegradability,mucus-adhesion,and low cost[1,2].
Self-assembly of organic molecules has been widely used to fabricate various functional materials[1].For example,Kasai et al.reported the fabrication of pure nanodrugs from podophyllotoxin dimer (call
Multifunctional polymeric nanocarriers that integrate various desired functions have emerged as the next generation of nanomedicines to improve the therapeutic efficacy and clinical outcome.However,th
Ligand-targeted cancer therapeutics has been developed to minimize the non-specific cytotoxicity via ligand-drug conjugates during the past few decades.[1-3]We present here the design and synthesis of