Objective:Methods on how to improve the sequential targeting of glioma subsequent to passing of drug through the blood-brain barrier (BBB) have been occasionally reported.However,the characteristics involved are poorly understood.We prepared a cisplatin loaded liposomal carrier modified with transferrin(Tf),expecting it to transport through BBB and sequential target C6 glioma cells,and the characteristics of"sequential-targeting" for lipsomes(Tf) were further studied.