Vertebral body stent of shape memory alloy (SMA-VBS) is an innovative device which helps recover the compression fractural vertebral at normal height.Mechanical design of SMA-VBS is constructed to meet the functional and surgical requirement.A finite element modeling (FEM) is carried out to account for the stress-induced phase transformation of shape memory alloy.The vertebral support biological intervention system and computational model of compression resistance property of vertebral stent are built by the nonlinear FEM.It is shown that the FEM results are consistent with those of experimental observation for an original design of SMA-VBS so as to validate the accuracy of the FEM model.Subsequently,a series of numerical simulations and response surface methodology (RSM) are performed to optimize the proposed topological structures which meet the surgical condition of the lumen structure of fracture vertebral body.An innovative design optimization of stent is proposed where four S-type stents are series-parallel connected.The proposed structure can obtain the maximum support force of 1,000 N which can meet the functional requirement.In conclusion,the present study could clarify the compressive mechanical property of SMA-VBS and then help the researchers to design and optimize the topological structures of SMA-VBS systems.