NF1 Regulated Ras/MAPK Signaling in Cerebellum Development

来源 :中国细胞生物学学会2015年全国学术大会 | 被引量 : 0次 | 上传用户：deng5384588

【摘要】

：

Mutations in Neurofibromin 1 (NF1) have been implied in multiple human diseases, including cancers and neurological disorders.We have observed that brain specific deletion of NF1 affected the balance

【作者】

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Efrain Sanchez-Ortiz Woosung Cho Inga Nazarenko Wei Mo Jian Chen Luis F.Parada

【机构】

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Department of Developmental Biology, University of Texas Southwestern Medical School, Dallas, Texas

【出处】

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中国细胞生物学学会2015年全国学术大会

【发表日期】

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2015年4期

【关键词】

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NF1 Cerebellum development Ras-MAPK Granular neuron migration

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　　Mutations in Neurofibromin 1 (NF1) have been implied in multiple human diseases, including cancers and neurological disorders.We have observed that brain specific deletion of NF1 affected the balance and motor coordination of the knockout mice, which suggested a role of NF1 in cerebellum development.

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NF1 Regulated Ras/MAPK Signaling in Cerebellum Development

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