【摘 要】
：
Aim: To induce bone marrow tolerogenic dendritic cells (TDCs) and to investigate the mechanism by which bone marrow TDCs modulate the balance between regulatory T ceils (Tregs) and Th17 ceils in vitro
【机 构】
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Institute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Antiinflammatory and
【出 处】
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The 12th Meeting of the Asia Pacific Federation of Pharmacol
论文部分内容阅读
Aim: To induce bone marrow tolerogenic dendritic cells (TDCs) and to investigate the mechanism by which bone marrow TDCs modulate the balance between regulatory T ceils (Tregs) and Th17 ceils in vitro.Methods: Bone marrow TDCs were identified by the expression of CD11b, F4/80, IDO, IL-10 and TGF-β.Bone marrow TDCs modulate the differentiation of CD4+CD25+Foxp3+ Tregs in the coculture system were detected by CTLA-4, Foxp3 mRNA, Helios mRNA, IL-1O and TGF-β.
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