Increased ischemia-reperfusion lung injury in Aquaporin 1 null mice is mediated via decreased HIF-2a

来源 :2014中华医学会呼吸病学年会暨第十五次全国呼吸病学学术会议 | 被引量 : 0次 | 上传用户：kathy052

【摘要】

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【作者】

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Haiyan Ge Jiaxian Ou Nuo Xu Fanglei Liu Yanping Zhu Huili Zhu Chunxue Bai

【机构】

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Huadong Hospital, Fudan University Zhongshan Hosp

【出处】

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2014中华医学会呼吸病学年会暨第十五次全国呼吸病学学术会议

【发表日期】

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2014年3期

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Objectives Although early events in the pathogenesis of acute lung injury (ALl) have been defined, little is known about the mechanisms mediating resolution.Aquaporin 1 (AQP1), a water channel protein expressed widely in vascular endothelia, has been shown to regulate cell migration, angiogenesis as well as organ regeneration.We investigated the contribution of AQP1 in the resolution of lung ischemia-reperfusion injury.

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Increased ischemia-reperfusion lung injury in Aquaporin 1 null mice is mediated via decreased HIF-2a

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