【摘 要】
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Aim: To investigate the exposure-response relationship of benvitimod cream after topical administration in patients with mild or moderate psoriasis vulgaris.Methods: Thirty-six patients with mild or m
【机 构】
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Peking University People's Hospital,Beijing,100044,China;School of Pharmaceutical Sciences,Peking U
【出 处】
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中国工程院2014年医学科学前沿论坛第十四次全国临床药理学学术会议暨第六届国际药物警戒与药物安全学术会议
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Aim: To investigate the exposure-response relationship of benvitimod cream after topical administration in patients with mild or moderate psoriasis vulgaris.Methods: Thirty-six patients with mild or moderate psoriasis vulgaris were randomly assigned to receive 30 g/1.7 m2-of benvitimod cream (0.5％, 1.0％, and 1.5％) or placebo twice daily for six weeks.Exposure-response relationship analysis was applied to obtain parameters of benvitimod cream by the NONMEM method.
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