五味子甲素对P-糖蛋白的抑制作用

来源 :中国工程院2014年医学科学前沿论坛第十四次全国临床药理学学术会议暨第六届国际药物警戒与药物安全学术会议 | 被引量 : 0次 | 上传用户：huanghong198122

【摘要】

：

目的:以CaCo-2细胞转运模型为工具,体外研究五味子甲素对P-糖蛋白的作用.方法:建立Caco-2细胞转运模型,双向转运试验测定五味子甲素对P-gp的影响.建立一种快速、准确的HPLC方法测定细胞媒介中五味子甲素的浓度,计算五味子甲素的表观穿透系数(PDR),推测其为P-糖蛋白底物的可能性;同时测定五味子甲素对P-gp底物——罗丹明123转运的影响,体外测定五味子甲素对P-gp的作用.

【作者】

：

李维亮辛华雯马晓琴

【机构】

：

广州军区武汉总医院临床药理科,湖北武汉,430070

【出处】

：

中国工程院2014年医学科学前沿论坛第十四次全国临床药理学学术会议暨第六届国际药物警戒与药物安全学术会议

【发表日期】

：

2014年3期

【关键词】

：

五味子甲素 P-糖蛋白 Caco-2细胞 HPLC

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五味子甲素对P-糖蛋白的抑制作用

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