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Dysregulated EGFR signaling,especially EGFR/AKT signaling,plays an important role in tumorigenesis and progression,the study on intmcellular regulation of this signaling pathway has the great clinical significance.PTEN is the important antagonist of AKT activity.Its regulation on AKT activity can be enhanced by its association with PDZ protein EBP50 and further formation of PTEN/PDGF receptor complex mediated by EBP50.