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Background Cellular repressor of E 1A-stimulated genes (CREG),a new cardiovascular homeostasis regulator,has been proposed to reduce the neointimal formation after vascular injury via the maintenance of the quiescent mature vascular smooth muscle cell (VSMC) phenotype.We hypothesized that CREG is a negative regulator of angiotensin (Ang) Ⅱ-mediated vascular remodeling.