论文部分内容阅读
蛋白质泛素化作为一种常见的翻译后修饰，在调节细胞周期进程，蛋白降解以及DNA 修复等多种重要生理过程中起着关键作用。异常的蛋白质泛素化与许多人类疾病的发生发展密切相关。因此，在蛋白质组学水平上对泛素化进行定性定量分析，有助于深入了解泛素化参与的各种生理过程。
基于肽段等重标记的蛋白质泛素化串级质谱定量新方法
【摘 要】
：
蛋白质泛素化作为一种常见的翻译后修饰，在调节细胞周期进程，蛋白降解以及DNA 修复等多种重要生理过程中起着关键作用。异常的蛋白质泛素化与许多人类疾病的发生发展密切相关。因此，在蛋白质组学水平上对泛素化进行定性定量分析，有助于深入了解泛素化参与的各种生理过程。
【机 构】
：
复旦大学化学系,上海市杨浦区邯郸路220号,200433 复旦大学生物医学研究院,上海市徐汇区东安
【出 处】
：
第三届全国质谱分析学术报告会
【发表日期】
：
2017年10期
其他文献
Electrowetting-Induced Morphological Evolution of Metal-Organic Inverse Opals towards a Water-Lithog
In this paper,we put forward a novel method for the fabrication of metal-organic inverse opals(MOIOs)by infiltration of Pb(NO3)2 into the interstice of the poly(St-MMA-AA)PC template and the subsequen
Development of “Stop-flow” Microtubing Reactor Platform for Reaction Discovery under Visible-light P
The use of photons as “traceless and green reagents” renders photochemical processes green and sustainable.Light activation of molecules provides access to reaction pathways which are otherwise imposs
Strategy to Attain Remarkably High Photoinduced Charge-Separation Yield of Donor-Acceptor Linked Mol
Recently,we exploited a novel strategy to control the cell membrane potential by utilizing intramolecular photoinduced electron-transfer(PET) in the amphiphilic donor-acceptor linked molecules consist
会议
An efficient water reduction system was developed using thermally activated delayed fluorescence(TADF) dyes as organic photosensitizers and a palladium-phosphine complex as water reduction catalyst.
会议
Artificial photosynthesis is a chemical process that seeks to capture and store energy from sunlight to meet rising globe energy demand.[1] An active and stable photosensitizer is significant for effi
构建一维金属-半导体异质结是提高光催化剂电荷分离和转移效率的有效途径。[1-2]我们通过在金棒两端选择性的负载TiO2纳米粒子，得到了哑铃状的Au-TiO2复合光催化剂(图1)，并且在自然光照且无牺牲剂存在下实现了高效的光催化分解水产氢效率。此外，通过研究不同波长光照下的催化效率，我们确定了光生电荷转移的主要方向。
Super Fluid Extraction(SFE) technique is very useful as an extraction method for various analyses,because it is able to extract the target compounds automatically from many kinds of sample forms as su
会议
复杂环境和生物介质中痕量目标物的原位分析一直以来都是分析化学、生命科学、环境科学等领域的一项极具挑战任务.原位离子化固相微萃取探针是一种新型的固相微萃取(SPME)探针,它既可快速地从复杂基体杂样品中萃取和富集痕量目标物,又可作为固体基质在常压敞开条件下对目标物解吸并诱导产生电喷雾(ESI)或纳升电喷雾(nanoESI)离子化进行直接质谱分析,整合了SPME 和原位电离质谱(AMS)的优点[1,2
会议
有机气溶胶(OA)是大气气溶胶的重要组成部分,对全球气候变化和人体健康有着重要影响。[1,2]然而,OA 的化学组分非常复杂,包含成千上万个不同种类的化合物,如碳氢化合物、醇类、醛类、羧酸、有机硫酸酯(organosulfates)、有机硝基硫酸酯(organonitrates)、类腐殖质(HULIS)和低聚物(oligomers)等。
Broad screening and confirmation of illicit ingredients in cosmetics using UPLC-Q-Orbitrap HRMS with
Broad screening,identification and quantitation of 100 multi-class regulated ingredients in cosmetics was achieved in a highly sensitive and selective manner using ultra high pressure liquid chromatog