【摘 要】
：
Background: Type Ⅱ diabetes mellitus (DM) is thought to be a risk factor for thromboembolism (VTE).Elevated plasma levels of plasminogen activator inhibitor-1 (PAI-1) are associated with DM.However, t
【机 构】
：
Drug Discovery Research Center, Sichuan Medical University, Luzhou, Sichuan, China
【出 处】
：
第十五届中国中西医结合学会微循环专业委员会暨第二届中国微循环学会痰瘀专业委员会学术会议
论文部分内容阅读
Background: Type Ⅱ diabetes mellitus (DM) is thought to be a risk factor for thromboembolism (VTE).Elevated plasma levels of plasminogen activator inhibitor-1 (PAI-1) are associated with DM.However, the role of PAI-1 in the development of DM-associated VTE is poorly defined.Aims: Our aim was to determine the role of PAI-1 in the DM-associated VTE, and to test the hypothesis that inhibiting PAI-1 promotes venous thrombosis resolution.
其他文献
Aim: Arteriosclerosis obliterans (ASO) of the lower extremities is a major cause of adult limb loss worldwide.A timely diagnosis in the early stages of the disease determines the clinical outcomes, ho
目的：白藜芦醇(Res)具有多种药理学作用。本研究从存活时间、平均动脉血压(MAP)、整体升压反应、离体微血管反应性等方面,观察Res对脂多糖(LPS)攻击小鼠的干预作用。方法：首先,24只BALC/c雄性小鼠均分为：假手术组(Sham)、Sham+Res、LPS、LPS+Res组,其中：LPS与LPS+Res组小鼠均腹腔注射LPS (35 mg/kg,5 mg/ml,Sigma),1h后,LPS
目的：观察Bcl-2抑制剂对黄芪注射液降低缺血再灌注大鼠海马神经元凋亡相关基因Caspase-3表达的影响，探讨黄芪注射液发挥脑保护作用的具体作用靶点.方法：取体外原代培养8d的海马神经元，随机分为六组：正常对照组、模型组(即：缺氧缺糖/复氧复糖组)、黄芪注射液治疗组、黄芪注射液溶剂(即：无菌去离子水)对照组、Bcl-2抑制剂组、Bcl-2抑制剂+黄芪注射液组.除正常对照组外均进行缺氧缺糖0.5
目的：研究香砂六君丸对糖尿病胃轻瘫大鼠血清代谢产物的影响。方法：应用气相色谱和质谱联用仪的代谢组学方法检测经香砂六君丸治疗2型糖尿病大鼠血清中代谢物的变化。分别通过偏最小二乘-判别分析方法(Partial Least Squares-linear-Discriminant Analysis,PLS-DA)及正交偏最小二乘法-判别分析(OPLS-DA),比较糖尿病胃轻模型组及香砂六君丸组大鼠的血清小
Objective: To investigate the TLR4(Toll like receptor 4)-TRAF6(tumor necrosis factor receptor associated-factor 6) signal pathway expression in rats intestinal ischemia and reperfusion (IR) injury, as
目的：通过测定对照人群、颈动脉狭窄病人术前和动脉支架植入术后血浆中miRNA的表达水平，探讨miRNA在颈动脉狭窄病人及动脉支架植入术后血浆中的表达特征，寻找能指示颈动脉狭窄的miRNA.方法：收集2014年8月-2015年9月来我院就诊的颈动脉狭窄并进行动脉支架植入术病人28例和对照人群30例，用Real time PCR技术检测对照人群和颈动脉狭窄病人血浆中miR-146a、miR-4284、
Coagulation factor Ⅴ (fⅤ) is distributed in plasma and platelet pools distinguished by physical and functional differences.fⅤ has been extensively studied for its roles in coagulation.The roles of fⅤ
Diabetes mellitus (DM) leads to the development of microvascular diseases and is associated with impaired angiogenesis.The presence of VEGF can block PDGF-BB dependent regulation of neovascularization
Objective: Platelets can regulate endothelial cell genes expression through their adhesion to the subendothelium in response to vascular injury.Recently it has been reported that some endothelial cell
目的：探讨miR221-3p在下肢缺血性疾病中表达的变化.方法：用microarray筛选出闭塞性动脉硬化症(Arteriosclerosis obliterans,ASO)患者血浆中差异表达的miR221-3p.用实时荧光定量pcr检测临床55例ASO患者和54例健康对照人群血浆中miR221-3p的表达量.动物实验,实验组分离结扎大鼠股动脉制备下肢缺血模型,对照组仅暴露分离股动脉不做结扎.分别