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Neonatal jaundice could occur in most newborn infants.Phototherapy is a widely used treatment for it.Blue and green narrow-band LED chips,with central wavelength 460nm and 505nm,are selected for reliable and effective phototherapy.To meet the requirement of irradiance and uniformity,two different optical design schemes for neonatal jaundice phototherapy apparatus are proposed in this paper.The first design uses 13 LED modules arranged in a specific order while the other one is based on a pair of specially designed fly-eye lens optical systems.The simulation and experimental results indicate that phototherapy equipments designed in this paper have advantages in effective spectral range,illumination intensity and uniformity over those traditional ones.