【摘 要】
:
目的 评估骨折风险评估工具(FRAX(@))对绝经后低骨量女性的骨折预测价值.方法 回顾性收集绝经后低骨量上海女性769人.所有研究对象纳入的研究参数有年龄、身高、体重、脆性骨折史、父母脆性骨折史、口服激素史、类风湿关节炎史、吸烟史、饮酒史,腰椎1-4(L1-4)和左侧股骨颈骨密度(bone mineral density, BMD).应用骨折风险评估工具(FRAX(@))中国模式计算个体的10年
【机 构】
:
上海交通大学附属第六人民医院骨质疏松和骨病专科 200233
【出 处】
:
中华医学会第七次全国骨质疏松和骨矿盐疾病学术会议
论文部分内容阅读
目的 评估骨折风险评估工具(FRAX(@))对绝经后低骨量女性的骨折预测价值.方法 回顾性收集绝经后低骨量上海女性769人.所有研究对象纳入的研究参数有年龄、身高、体重、脆性骨折史、父母脆性骨折史、口服激素史、类风湿关节炎史、吸烟史、饮酒史,腰椎1-4(L1-4)和左侧股骨颈骨密度(bone mineral density, BMD).应用骨折风险评估工具(FRAX(@))中国模式计算个体的10年骨折概率,筛选达到骨质疏松性骨折高危患者诊断标准的个体;同时按年龄分为4组,50岁~ 59岁组,60岁~69岁组,70岁~79岁组和80~90岁组,分析不同年龄段10年髋部的骨折概率和10年主要骨质疏松性骨折的概率.
其他文献
Objective Fibrodysplasia ossificans progressiva, an ultra-rare and disabling genetic disorder of skeletal malformations and progressive heterotopic ossification (HO), is the most catastrophic conditio
Introduction It was reported that iron overload is a risk factor of osteoporosis.However, in these studies, animals vary from mice to rat and pig, and were experimentally iron overloaded.The results o
Objective Fracture healing is a complex process that involves both anabolic and catabolic responses.At the onset of fracture repair there is an initial inflammatory phase followed by the differentiati
Background Recombinant human parathyroid hormone (1-34) (rhPTH (1-34)) given by injection is a new seventh class drug of biological products, which is prepared by adopting gene recombination technique
Objective Dickkopf-1(DKK1) is antagonist to Wnt signaling pathway.Our aim was to investigate the association between DKK1 gene polymorphisms and bone response to alendronate treatment in Chinese postm
目的 判断骨转化标志物检测对骨质疏松症的诊断、分型、鉴别诊断与指导治疗理论上的实际意义.方法 通过96份骨转换标志物的检测报告,分析血清骨钙素(OC)、骨钙素N端中分子片段(N-MID)、Ⅰ型胶原羟基端肽β降解产物(β-CTX)、I型胶原吡啶交联终肽(ICTP)的变化,并对OC与N-MID、β-CTX与ICTP的同效性进行比对.
目的 Ghrelin是生长激素促分泌素受体(GHSR)的内源性配体,在体内发挥多种生理学作用.近期的研究发现Ghrelin可促进小鼠成骨细胞(MC3T3-E1)增殖和分化,抑制MC3T3-E1凋亡,但具体机制尚不明确.本文旨在研究Ghrelin对MC3T3-E1凋亡的影响及其作用机制.方法 以10-9 ~ 10-11MGhrelin干预MC3T3-E1,分别以TUNEL法和ELISA法检测其细胞凋
Objective More recently, the relationship between osteoporosis and obesity, especially for central obesity, has become a new research hotspot.However, the conclusions remain controversial.S.Zhu et al
目的 评价35mg利塞膦酸钠片对绝经后骨质疏松症的有效性和安全性.方法 290例绝经后骨量减少及骨质疏松妇女,随机分成试验组145例和对照组145例.试验组每周服用利塞膦酸钠35 mg(昆明积大),对照组每天服用利塞膦酸钠5 mg(昆明积大),两组同时给予元素钙500 mg+维生素D 200IU,治疗时间1年.主要疗效指标:腰椎骨密度变化率.次要疗效指标:(1)股骨颈、全髋部BMD (2)骨代谢生
Objective Adenovirus expressing small interfering RNA(siRNA)-targeting BMPR-IB was locally administered into the air pouch of mice to improve bone resorption induced by ultrahigh molecular weight poly