Compound Astragalus and Salvia Miltiorrhiza Extract suppresses cell migration of keloid fibroblasts:

来源 :The 12th Meeting of the Asia Pacific Federation of Pharmacol | 被引量 : 0次 | 上传用户：k99youaik99

【摘要】

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【作者】

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Shu-fang HE Yan YANG Jie-mei JIANG Sen YANG Xue-jun ZHANG

【机构】

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Department of Anesthesiology,the Second Affiliated Hospital of Anhui Medical University,Hefei 230032

【出处】

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The 12th Meeting of the Asia Pacific Federation of Pharmacol

【发表日期】

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2013年4期

【关键词】

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keloid compound Astragalus and Salvia miltiorrhiza extract cell migration transf

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Aim: To investigate the effects of Compound Astragalus and Salvia Miltiorrhiza Extract (CASE) on cell migration of keloid fibroblasts (KFs) and its mechanisms involving mitogen-activated protein kinase (MAPK) pathways including extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK) and p38 kinase.Methods: KFs were cultured and then treated with transforming growth factorbeta 1 (TGF-β1) with or without CASE (7.5, 15, and 30 μg/mL) treatment.

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Compound Astragalus and Salvia Miltiorrhiza Extract suppresses cell migration of keloid fibroblasts:

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