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  5. Multipoint Targeting of the PI3KmTOR Pathway in Mesothelioma

Multipoint Targeting of the PI3KmTOR Pathway in Mesothelioma

来源 :第十一届全国酶学学术讨论会暨邹承鲁诞辰90周年纪念会 | 被引量 : 0次 | 上传用户：xuxiaohua
【摘 要】
：
Mesothelioma is a notoriously chemotherapy-resistant neoplasm, as is evident in the dismal overall survival for patients with this asbestos-associated disease.W
【作 者】
：
Shengmei Zhou Jonathan A.Fletcher Wen-Bin Ou Li Liu Hailong Li Grant Eilers Si Shi Ziqing Yan Joseph M.Corson Fanguo Meng Haimeng Zhou 
【机 构】
：
CollegeofBiologyandChemicalEngineering,JiaxingUniversity,Jiaxing,ChinaDepartmentofPathology,Brighama
【出 处】
：
第十一届全国酶学学术讨论会暨邹承鲁诞辰90周年纪念会
【发表日期】
：
2013年5期
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Mesothelioma is a notoriously chemotherapy-resistant neoplasm, as is evident in the dismal overall survival for patients with this asbestos-associated disease.We previously demonstrated co-activation of multiple receptor tyrosine kinases (RTK), including EGFR, MET, and AXL in mesothelioma cell lines,suggesting that these kinases could serve as novel therapeutic targets.
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