Chronic subclinical inflammation represents a risk factor of type 2 diabetes and several diabetes complications,including neuropathy,atherosclerosis in macro—vasculopathy,and micro-vasculopathy HoweveL the inflammatory response in the diabetic wound was shown to be remarkably hypocellular,unregulated and ineffective Advanced glycation end products(AGEs)and its receptoL RAGE,was involved in 1nducing chronic 1mmune 1mbalance of diabetic patients Such Interaction attract 1mmune cell Into diflused glycated tissue and activate these cells to 1nduce 1nflammatory damage.whereas disturb the normal 1mrflL!ne rhvthm 1n diabetic wound Traditional measurements ofAGEs are HPLC and 1mmunohistochemistrv staining, but their application faces the limitations including complexity,cost and lack of reproducibility A newnoninvasive method emerged 1n 2004.using skin autofluorescence as 1ndicator for AGEs accumulation It had been reported to be 1nformative 1n evaluating the chronic risk of diabetic patients Studies have 1ndicated therapeutic potentials ofAnti AGE recipes These recipes can reduce AGEs absorption/de HOVO formation.block AGEs—RAGE Interaction and arrest downstream signaling after RAGE activation