2. 您的位置
3. 首页
4. 会议论文
5. A Novel Strategy to Block NF-κB Signaling Pathway by Preventing IKKβ Activation

A Novel Strategy to Block NF-κB Signaling Pathway by Preventing IKKβ Activation

来源 :中国生物化学与分子生物学会第十二届会员代表大会暨2018年全国学术会议 | 被引量 : 0次 | 上传用户：liujia6949

【摘 要】

：

Transcription factor NF-κB plays a key role in various biological processes in cell.NF-κB misregulation is involved in a variety of diseases such as chronic inflammation and cancer.The I kappa B kinas

【作 者】

：

Hongbo Liu Hao Liang Hu Meng Xiaobing Deng Xiaoling Zhang Luhua Lai 

【机 构】

：

Peking-Tsinghua Center for Life Sciences,Peking University,Beijing 100871

【出 处】

：

中国生物化学与分子生物学会第十二届会员代表大会暨2018年全国学术会议

【发表日期】

：

2018年10期

【关键词】

：

NF-κB IKKβ Allosteric inhibitor 

下载到本地 , 更方便阅读

下载此文 赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

　　Transcription factor NF-κB plays a key role in various biological processes in cell.NF-κB misregulation is involved in a variety of diseases such as chronic inflammation and cancer.The I kappa B kinase β(IKKβ)is one of the primary regulators of NF-κB activity.

其他文献

一种软骨修复用水凝胶的制备及其用于软骨损伤修复的研究

背景：由于无血管结构和无神经组织，关节软骨缺乏自我再生的内在能力，关节软骨损伤的修复仍然是一个重大挑战。目前，许多治疗方法用来解决软骨修复问题，如自体移植和同种异体移植，但仍存在供体不足，手术操作复杂，手术费用昂贵等显着缺点。幸运的是，软骨组织工程提供了一种有前途的替代策略。

会议

水凝胶软骨细胞间充质干细胞脱钙骨基质颗粒软骨修复

Poly(C)Binding Proteins Regulate the Period of Circadian Clocks

Circadian rhythms are endogenous,entrainable,rough 24h oscillations that coordinate daily changes in physiology and behavior.These oscillations exist widely in most organisms and are governed by the i

会议

poly (C)CircadianPeriod

通过噬菌体展示和酵母细胞展示技术在细胞中构建一条全新的泛素化途径

泛素化是细胞中非常重要的翻译后修饰过程，参与蛋白质降解、细胞信号传导等功能。泛素通过泛素激活酶E1、泛素结合酶E2以及泛素连接酶E3的级联反应，传递到蛋白底物，形成泛素长链。在泛素化过程中，泛素连接酶E3具有底物特异性，起到了决定作用。

会议

泛素化泛素噬菌体展示技术酵母细胞展示技术

Effect of physiological concentration of melatonin on the quality of stored erythrocyte in vitro

Objective To investigate whether physiological concentration of melatonin(MT)has a protective effect on the stored red blood cell(RBCs)in vitro.Methods Healthy adults were recruited,and 200 ml of whol

会议

MelatoninRed blood cellsBlood preservation

Effects of promoters,the Woodchuck hepatitis post-transcriptional regulatory element,and weakened se

Chinese hamster ovary(CHO)cells are the host of choice for the production of recombinant proteins in mammalian expression systems.Here,we investigated the effects of promoters,the Woodchuck hepatitis

会议

Chinese hamster ovaryWPREPromoterWeakenedResistance geneTransgene

de novo sequencing with mirror image protease of LysargiNase and trypsin for large scale proteomics

De novo peptide sequencing for an individual pure protein has improved remarkably with the progress of mass spectrometry but there still exists incomplete peptide fragmentation and indistingushiable s

会议

de novo sequencingproteomicsmirror enzymeLysargiNase

基于蛋白质组学分离和鉴定韧革菌素环合酶

韧革菌素(Vibralactone,3)是从高等真菌褐盖韧革菌(Boreostereum vibrans)中分离得到的一个结构新颖且具有强胰脂肪酶抑制活性的天然产物。前期研究表明韧革菌素的生物合成首先是由异戊烯基取代的对羟基苯甲醇(1)通过氧化扩环形成七元环中间体(1,5-secovibralactone,2),随后再通过分子内环合生成韧革菌素(3)。

会议

韧革菌素环合酶蛋白分离纯化蛋白质组

Design and evaluation of a novel HSV-2 epitope vaccine

We used LCP technology to design and synthesize a lipid core peptide vaccine with self-assembly and intramolecular adjuvant properties for HSV-2 epitope,and evaluate the immune effect.In this study,LC

会议

Herpes simplex virus type 2 (HSV-2)humoral immunitycellular immunityvirus-neu

Detection of Promoter Methylation Status of Suppressor of Cytokine Signaling 3(SOCS3)in Tissue and P

SOCS3 as an important negative regulator of IL6/JAK/STAT3 signaling pathway may be early critical determinants of carcinogenesis.This study aimed to explore the aberrant promoter methylation of SOCS3

会议

hepatocellular carcinomaSOCS3methylationplasmaprognosis

Isolation and identification of two feather-degrading strains of bacterium from spider gut and the p

Microbial enzymes play an increasingly important role in industrial production,agriculture and daily life nowadays.Particularly,some of these enzymes are derived from human-safe microorganisms.In our

会议

Stenotrophomonas maltophiliaBacillus subtilisfeather degradationKeratinasesp