Incorporating historical data in Bayesian phase Ⅰ trial design:Evaluating the similarity in dose-tox

来源 :上海交通大学 | 被引量 : 0次 | 上传用户：sdfcasdvgase

【摘要】

：

In oncology area,following a phase Ⅰ dose-finding trial completed in a certain population of patients,further phase Ⅰ trials are often conducted to determine the maximum tolerated dose(MTD)for differe

【作者】

：

Kentaro Takeda Satoshi Morita

【机构】

：

Data Science,Astellas Pharma Global Development,Inc.,Illinois,60062,U.S.A.

【出处】

：

上海交通大学

【发表日期】

：

2016年4期

【关键词】

：

Phase Ⅰ clinical trial dose-finding Bayesian trial design historical data borrow

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Incorporating historical data in Bayesian phase Ⅰ trial design:Evaluating the similarity in dose-tox

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