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  5. Eplgallocatechln-3-gallate inhibits homocysteine-induced apoptosis of endothelial cells by demethyla

Eplgallocatechln-3-gallate inhibits homocysteine-induced apoptosis of endothelial cells by demethyla

来源 :The 12th Meeting of the Asia Pacific Federation of Pharmacol | 被引量 : 0次 | 上传用户：helinjue
【摘 要】
：
Aim: Our previous study showed hypermethylation of dimethylarginine dimethylaminohydrolase 2 (DDAH2) contributes to homocysteine (Hcy)-induced apoptosis of endothelial cells (ECs).Epigallocatechin-3-g
【作 者】
：
Bi-kui ZHANG Yong-quan LAI Pan-pan NIU Ming ZHAO Su-jie JIA 
【机 构】
：
Department of Pharmaceutics, The Third Xiangya Hospital, Central South University, Changsha 410013,C
【出 处】
：
The 12th Meeting of the Asia Pacific Federation of Pharmacol
【发表日期】
：
2013年4期
【关键词】
：
EGCG DNA methylation DDAH2 
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Aim: Our previous study showed hypermethylation of dimethylarginine dimethylaminohydrolase 2 (DDAH2) contributes to homocysteine (Hcy)-induced apoptosis of endothelial cells (ECs).Epigallocatechin-3-gallate (EGCG) is a green tea-derived phenol which has beneficial on atherosclerosis.It was demonstrated that EGCG inhibits DNA methyltransferase (DNMT) activity and reactivate methylation-silenced genes in cancer cells.
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