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  5. Effects and the mechanism of lignans from Eucommia ulmoides on rat mesangial cell proliferation indu

Effects and the mechanism of lignans from Eucommia ulmoides on rat mesangial cell proliferation indu

来源 :The 12th Meeting of the Asia Pacific Federation of Pharmacol | 被引量 : 0次 | 上传用户：goodcareer
【摘 要】
：
Aim: To study the effects of lignans from Eucommia ulmoides on the proliferation in rat mesangial cell induced by Ang Ⅱ, providing theoretical basis for the application of lignans from Eucommia ulmoid
【作 者】
：
Xian JING Ying-ying TIAN Wei-hua HUANG Hong-hao ZHOU Dong-dheng OUYANG 
【机 构】
：
Institute of Clinical Pharmacology,Central South University,Hunan Key Laboratory of Pharmacogenetics
【出 处】
：
The 12th Meeting of the Asia Pacific Federation of Pharmacol
【发表日期】
：
2013年4期
【关键词】
：
Ang Ⅱ celluar proliferation cell cycle cell apoptosis lignans from Eucommia ulmo 
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Aim: To study the effects of lignans from Eucommia ulmoides on the proliferation in rat mesangial cell induced by Ang Ⅱ, providing theoretical basis for the application of lignans from Eucommia ulmoides in renoprotection.Methods: Rat glomerular mesangial cell (HBZY-1) were cultured in vitro and divided into 5 groups: control group, Ang Ⅱ group (10-8 mol/L Ang Ⅱ), low concentration lignans group (10-8 mol/L Ang Ⅱ+20 mg/L lignans), middle concentration lignans group (10-8 mol/L Ang Ⅱ+40 mg/L lignans), high concentration lignans group (10-8 mol/L Ang Ⅱ+80 mg/L lignans).
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