【摘 要】
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Here we developed a ring-opening polymerization strategy for preparation of biocompatible and aminofunctionalized superparamagnetic iron oxide nanoclusters (SPIONCs).The functionalized SPIONCs could b
【机 构】
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The Education Ministry Key Lab of Resource Chemistry and Shanghai Key Laboratory of Rare Earth Funct
【出 处】
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第六届全国低场核磁共振技术与应用研讨会
论文部分内容阅读
Here we developed a ring-opening polymerization strategy for preparation of biocompatible and aminofunctionalized superparamagnetic iron oxide nanoclusters (SPIONCs).The functionalized SPIONCs could be further applied for folate-receptor (FR)-targeted magnetic resonance imaging (MRI).The citrate-stabilized SPIONCs were synthesized by solvothermal reaction using biocompatible trisodium citrate (Na3Cit) as the coordinating and stabilizing ligand and then the amino groups were covalently bonded to them through a ring-opening polymerization of epichlorohydrin and further treatment with ammonium hydroxide.The products were confirmed by XPS,FTIR,Zeta potential,and amino quantitative analysis.The amino-functionalized SPIONCs have good stability in aqueous solution and low cytotoxicity to cell lines.By in vitro MRI and quantitative element analysis,we demonstrated the FR-mediated delivery of the folic acid-conjugated SPIONCs (Fe3O4–FA) targeting FR-positive cell line such as human ovarian carcinoma cell.In conclusion,high magnetization,good stability,and effective FR-mediated uptake of the functionalized SPIONCs made them promising candidates for use as MRI contrast agents.
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