【摘 要】
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Warm ischemia leads to renal function injury in laparoscopic partial nephrectomy (LPN).To evaluate functional outcome, safety and efficacy of zero Ischemia, laparoscopic radiofrequency ablation assist
【机 构】
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Department of Urology,Renji Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai,China
【出 处】
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第十三届亚洲泌尿外科学会年会(UAA2015)、第二十二届全国泌尿外科学术会议(CUA2015)、第十六届全军及武警泌尿
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Warm ischemia leads to renal function injury in laparoscopic partial nephrectomy (LPN).To evaluate functional outcome, safety and efficacy of zero Ischemia, laparoscopic radiofrequency ablation assisted tumor enucleation (LRATE) in comparison with conventional LPN.A prospective randomized controlled trial was conducted from April 2013 to March 2015 in patients with cT1a renal tumor scheduled for laparoscopic nephron sparing surgery.Patients were randomized to LRATE or LPN group.Patients were followed for 12 months.Group LRATE underwent tumor enucleation following radiofrequency ablation for 1 to 4 cycles without renal hilar clamping.Group LPN underwent renal artery clamping.Primary outcome was the change in glomerular filtration rate (GFR) of the affected kidney by renal scintigraphy at 12 months postoperatively.Secondary outcomes included changes of estimated GFR (eGFR), serum creatinine, GFR of the affected kidney, estimated blood loss,operative time, postoperative complications, hospital stay and oncologic outcomes.
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