【摘 要】
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Objective: To determine plasma markers of oxidative stress during the second and third trimester of pregnancy in patients with gestational diabetes (GDM).Study Design: We conducted a prospective neste
【机 构】
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Department of Obstetrics & Gynecology, Nanfang Hospital, Southern Medical University,Guangzhou, Chin
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Objective: To determine plasma markers of oxidative stress during the second and third trimester of pregnancy in patients with gestational diabetes (GDM).Study Design: We conducted a prospective nested case-control study involving 400 pregnant women,22 of whom developed GDM.As control group,30 normal pregnant women were chosen randomly.Plasma samples were analyzed for specific oxidative plasma markers at 16-20 weeks,24-28 weeks,and 32-36 weeks of gestation.Results: Compared to control subjects,the plasma levels of AOPPs was elevated at 16-20 weeks and 32-36 weeks gestation in GDM.PCO was statistically significantly increased at 16-20 weeks and 32-36 weeks in GDM.PON I reduced in patients with GDM.No significant differences were found at 24-28 and 32-36 weeks between the GDM and control groups.In GDM,AOPPs and PONI levels were higher and GPX-3 and 8-iso-PGF2α levels were lower in the second than the third trimester.Conclusion: Oxidation status increased in GDM,especially protein oxidation,which may contribute to the pathogenesis of GDM.
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