Objective: Facial flat wart is a common but refractory disease caused by human papilloma virus.There are many therapies for the treatment of flat wart with varying curative ratio.Less than 60% patients obtained completely restoration treated by traditional therapies.CO2 laser and photodynamic therapy have been adopted in treating flat wart with no absolutely restoration respectively.A preliminary study was undertaken to assess the efficacy of combination therapy of super pulsed carbon dioxide laser and photodynamic for recalcitrant facial flat wart.