• 不 限
  • 期刊论文
  • 硕博论文
  • 会议论文
  • 报 纸
  • 英文论文
  2. 您的位置
  3. 首页
  4. 会议论文
  5. Dissociative role for dorsal hippocampus in mediating heroin craving and relapse through CDK5 and Rh

Dissociative role for dorsal hippocampus in mediating heroin craving and relapse through CDK5 and Rh

来源 :第十七届全国神经精神药理学学术会议 | 被引量 : 0次 | 上传用户：auroragame_luoxl
【摘 要】
：
OBJECTIVE Addiction is characterized by drug craving,compulsive drug taking and relapse,which is attributed to aberrant neuroadaptation in brain regions implicated in drug addiction,induced by changin
【作 者】
：
CHEN Zhong-guo LIU Xing WANG Wei-sheng GENG Fan GAO Jing GAN Chen-ling CHAI Jing-rui HE Ling HU Gang ZHOU Hu LIU Jing-gen 
【机 构】
：
Key Laboratory of Receptor Research,Shanghai Institute of Materia Medica and Collaborative Innovatio
【出 处】
：
第十七届全国神经精神药理学学术会议
【发表日期】
：
2016年5期
【关键词】
：
CDK5 dorsal hippocampus heroin self-administration label-free proteomic analysis 
下载到本地 , 更方便阅读
下载此文 赞助VIP
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
　　OBJECTIVE Addiction is characterized by drug craving,compulsive drug taking and relapse,which is attributed to aberrant neuroadaptation in brain regions implicated in drug addiction,induced by changing gene and protein expression in these regions after chronic drug exposure.Accumulating evidence suggests that the dorsal hippocampus(DH)plays an important role in mediating drug-seeking and taking behavior and relapse.
其他文献
Alterations of prefrontal cortical microRNAs in methamphetamine self-administering rats:from control
OBJECTIVE Drug addiction is a process that transits from recreative and regular drug use into compulsive drug use.The two patterns of drug use,controlled drug intake and escalated drug intake,represen
会议
methamphetamine addictionescalated drug usecontrolled drug useprefrontal cort
Κ Opioid receptor activation in different brain regions differentially modulates anxiety-related beh
OBJECTIVE Dynorphin/κ opioid receptor system is implicated in the modulation of emotion.The anxiety-related effects of κ receptor remain controversial as agonists show opposite effects in different st
会议
P38 mitogen-activated protein kinase activation in amygdala mediates κ opioid receptor agonist U50,4
OBJECTIVE Κ Opioid receptor agonists produce aversive effects in rodents,however the underlying mechanisms remain unclear.Activation of p38 mitogen-activated protein kinase(MAPK)has been discovered to
会议
κ opioid receptorU50488Hconditioned place aversionp38 MAPK
Imidazoline receptor antisera-selected protein (IRAS) modulates opioid tolerance and dependence by r
OBJECTIVE Our previous studies showed that imidazoline receptor antisera-selected protein(IRAS)had a potential role in modulating opioid tolerance and dependence in vivo,while the underlying mechanism
会议
μ opioid receptoropioid tolerancedependenceimidazoline receptor antisera-sele
镉染毒暴露对大鼠血管性痴呆模型学习记忆的影响
目的 研究重金属镉染毒对大鼠血管性痴呆模型学习记忆的影响。方法 雄性SD 大鼠80 只,随机分为空白对照组和模型对照组,模型组大鼠连续灌胃给予不同浓度的镉溶液(1,5 和25 mg·L-1),每日1 次,连续1 个月,染毒后大鼠采用双侧颈总动脉血管结扎法建立血管性痴呆模型,随后将动物随机分为4 组,分别为空白+VD 组、氯化镉低浓度+VD 组、氯化镉中浓度+VD 组和氯化镉高浓度+VD 组。
会议
镉染毒血管性痴呆水迷宫学习记忆
防治乙醇中枢毒性损伤新靶点--抗坏血酸转运体2
目的 研究抗坏血酸转运体2(SVCT2)在乙醇神经毒性损伤中的神经保护作用及其调节机制。方法 首先建立4 d 狂饮大鼠模型，采用高效液相色谱、激光共聚焦显微成像、基因芯片、ELISA、RT-PCR 和Western 蛋白印迹等实验技术，从神经行为学和分子生物学等角度研究乙醇神经损伤与氧化应激的关系，深入研究SVCT2 在乙醇致中枢神经系统损伤过程中的保护作用及其调节机制。
会议
抗坏血酸乙醇抗坏血酸转运体2氧化应激rno-miR-125a-5p神经退行性病变
Involvement of dorsal hippocampal CaMK Ⅱ activation in aversive memory formation induced by conditio
OBJECTIVE To investigate the role of calcium/calmodulin(CaM)-dependent protein kinase Ⅱ(CaMK-Ⅱ)in the formation of aversive memory induced by naloxone-precipitated morphine withdrawal.METHODS Male SD
会议
aversive memorydorsal hippocampusCaMKⅡKN-93
Blockade of HCN channels in nucleus accumbens cholinergic neurons preventscue-inducedrelapse of coca
OBJECTIVE To study the relationship between HCN channels of nucleus accumbens(NAc)cholinergic interneurons(CINs)and addiction relapse.METHODS The SD rats were used to establish cue-induced addiction r
会议
HCN channelsnucleus accumbenscholinergic interneuronscocainerelapseAMPA/NMD
A novel rodent model of impulsivity induced with pramipexole in a Y-maze avoidance task
Impulse control disorders have been gradually associated with pramipexole therapy of Parkinson disease,and this has been confirmed in various rodent models of impulsivity,such as the delay-discounting
会议
impulse control disorderspramipexoleYmazebehavioral addictionrodent modelim
催产素调节甲基苯丙胺所致成瘾性记忆改变的表观遗传学研究
目的 在甲基苯丙胺(METH)诱导的条件位置偏爱(CPP)形成阶段,从表观遗传学角度出发,探索催产素是否通过调节METH 诱导的学习记忆改变进而发挥抑制METH 成瘾的作用。方法 行为学检测包括条件位置偏爱和水迷宫,Day1-2 小鼠适应CPP 环境,Day3 小鼠进行CPP 前测并适应水迷宫环境,Day4-9 进行CPP 匹配与定位航行实验,Day10 进行CPP 检测以及空间探索实验。
会议
催产素甲基苯丙胺学习记忆表观遗传学