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5. Development of hydrophobic drug EVT lyophilized nanosuspension for enhanced dissolution rate and ora

Development of hydrophobic drug EVT lyophilized nanosuspension for enhanced dissolution rate and ora

来源 :2016年中国药物制剂大会、中国药学会药剂专业委员会2016年学术年会、中国化学制药工业协会固体制剂专业委员会2016年 | 被引量 : 0次 | 上传用户：woshi52038

【摘 要】

：

Objectives EVT,a strong antagonist to P2X7 receptor for non-steroidal anti-inflammatory was discovered through high-throughput screening.However,as a BCS II drug,EVT possesses poor and pH-independent

【作 者】

：

Yue Han Xu Zhang Yang Ding Jianping Zhou 

【机 构】

：

State Key Laboratory of Natural Medicines,Department of Pharmaceutics,China Pharmaceutical Universit

【出 处】

：

2016年中国药物制剂大会、中国药学会药剂专业委员会2016年学术年会、中国化学制药工业协会固体制剂专业委员会2016年

【发表日期】

：

2016年4期

【关键词】

：

Hydrophobic drug lyophilized nanosuspension solubility bioavailability 

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　　Objectives EVT,a strong antagonist to P2X7 receptor for non-steroidal anti-inflammatory was discovered through high-throughput screening.However,as a BCS II drug,EVT possesses poor and pH-independent aqueous solubility,hindering its further clinical application.

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