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The basic principle of tempo-spatially mixed modulated Fourier transform imaging spectrometer(FTIS)based on savart plates is outlined.A calibration method of pixel response nonuniformity of charge-coupled device(CCD)camera in such type of instrument is presented.The method which uses column-flat-fields can avoid the influence of interference fringes.The use of polychromatic calibration source can solve the problem of the slant of the fringes in big optical path difference areas.