Evading TGF-β-mediated growth inhibition is often associated with tumorigenesis in liver,including hepatocellular carcinoma(HCC).To better understand the functions and the underlying molecular mechanisms of TGF-β in HCC initiation and progression,we carried out transcriptome sequencing(RNA-Seq)to identify the target genes of TGF-β.CXXC5,a member of the CXXC-type zinc finger domain-containing protein family,was identified as a novel TGF-β target gene in Hep3B HCC cells.