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Pharmaceutical cocrystallization is proposed as a new method to enhance membrane permeability of a BCS class Ⅲ model drug,5-fluorouracil (5FU).Three cocrystals of 5FU,5FU/3-hydroxybenzoic acid (1),5FU/4-aminobenzoic acid (2) and 5FU/cinnamic acid (3),were successfully synthesized by a slurry method or a liquid-assisted grinding process.Spectroscopic methods,thermal analysis,and X-ray diffraction were used to characterize these new forms.