Voltage-gated potassium (Kv) channels regulate membrane excitability that defines the fundamental mechanism of brain functions such as cognition and pain signaling.Native Kv channels are in a form of complex composed of tetrameric core of pore-forming α subunits and additional auxiliary subunits.Binding of auxiliary subunits can change the functional properties of Kv channels at the membrane surface,trafficking and gating, thus resulting in a diverse modulation of channel function.