【摘 要】
：
Formaldehyde is implicated in epigenetics and in the pathologies of various chronic diseases such as neurodegenerative diseases,cancers and diabetes.Although several pathways in production of formalde
【机 构】
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State Key Laboratory of Brain and Cognitive Sciences,Institute of Biophysics,Chinese Academy of Scie
【出 处】
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中国生物化学与分子生物学会2016年全国学术会议
论文部分内容阅读
Formaldehyde is implicated in epigenetics and in the pathologies of various chronic diseases such as neurodegenerative diseases,cancers and diabetes.Although several pathways in production of formaldehyde have been studied,no laboratory has reported formaldehyde produced from ribose which widely exists in living things.Recently,abnormally high level of ribose has been found in type 2 diabetic patients,suggesting that the patients are suffered from not only dysmetabolism of glucose but also ribose.In this work,we present that formaldehyde is produced from decomposition of ribose.Ribose is first decomposed into glyceraldehyde followed by production of formaldehyde.This reaction occurs in 20 mM Tris-HCl buffer under an alkyline condition.Further experiments showed that formaldehyde is yield in the presence of lysine.It was showed that formaldehyde was yield significantly in the α-amino group)compared with 6-ε-amino group).This α-amino group of amino acids playing an important role in decomposition of ribose.Experiment with glycine further confirmed this viewpoint.These data appears that a high level of ribose may result in an increase of formaldehyde in vivo.
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