The thiazolidinedione class PPARγ agonists as antidiabetic agents are restricted in clinical use because of the side effects such as edema,weight gain and heart failure.
Breast cancer is the most common cancer among women.However,only two-thirds breast cancers,which belong to the hormone-positive(ER+)type,respond to treatment with tamoxifen.
Gossypol,a natural product isolated from cotton seeds and roots,binds to Bcl-2 and Bcl-x with quite high affinities that overcoming resistance of cancer cells to apoptosis.
Non-nucleoside reverse transcriptase inhibitors(NNRTIs)have received wide attention due to their unique antiviral potency,high specificity and low cytotoxicity[1].