Redox-sensitive hyaluronic acid-paclitaxel conjugate micelles with high physical drug loading for ef

来源 :2015年中国药物制剂大会、中国药学会药剂专业委员会2015年学术年会暨国际控释协会中国分会2015年学术年会 | 被引量 : 0次 | 上传用户:lyre1981
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
  The design of targeted polymer-drug conjugate capable of controlled drug release remains a benchmark for drug delivery systems.Although numerous polymer-drug conjugates exhibiting substantial drug-loading capacities have been proposed, insufficient release of encapsulated drugs in targeted areas remains a prominent shortcoming.
其他文献
Multidrug transporters (MDTs) including P-glycoprotein (P-gp) are a great hindrance to the drug penetration of the central nervous system (CNS).Nanodrug delivery system can enhance the brain delivery
会议
In this study, a reduction and pH dual-responsive tumor theranostic system based on degradable manganese dioxide (MnO2) nanosheets was developed for cancer theranostic application.The MnO2 nanosheets
Our study is to establish tumor pH-sensitive magnetic nanogranades (PMN) composed of pH-responsive ligands and iron oxide nanoparticles.These nanogranades can readily target tumors via surface-charge
The therapeutic effect of Arsenic trioxide(ATO,As2O3.) was limited because of its poor pharmaceutics and side effect caused by dose-limited toxicity and drug leakage during delivering process.Hollow m
会议
The objective of this study was to synthesis and to characterize the hydrophobically modified Fenugreek gum (FG) which contained galactose in the structure and could self-assemble into nano-sized mice
会议
OBJECTIVE To examine effect of pH on physiochemical properties of trans-resveratrol self-nanoemulsifying drug delivery system (RES SNEDDS).METHODS RES SNEDDS was prepared via pseudo-ternary phase diag
The aim of this study was to improve mucoadhesive properties of amphiphilic chitosan derivative by the covalent attachment of thiol moieties.N-deoxycholic acid-N,O-hydroxyethyl chitosan-thioglycolic a
会议
Hepatocyte microencapsulation and transplantation is considered as a promising therapy for severe liver function damage.In view of redundant hydrogels in existing cell microcapsules, transport efficie
Colloidosomes are microcapsules that consist of a hollow core coated by a shell composed of self-assembled colloidal particles.In recent years, they have attracted significant attention for the contro
Objective:To optimizate the membrane cleaning process of 0.2 μm Al2O3 ceramic membrane microfiltration of the Compound Banlangen Liyan Granules water extraction liquid.Method:According to the index of