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5. Cyclin D1 is a Mediator of Gastrointestinal Stromal Tumor KIT-independence

Cyclin D1 is a Mediator of Gastrointestinal Stromal Tumor KIT-independence

来源 :中国生物化学与分子生物学会第十二届会员代表大会暨2018年全国学术会议 | 被引量 : 0次 | 上传用户：kuxinghuajia

【摘 要】

：

Purpose: Oncogenic KIT or PDGFRA tyrosine kinase mutations are compelling therapeutic targets in most gastrointestinal stromal tumors(GISTs),and the KIT/PDGFRA inhibitor,imatinib,is therefore standard

【作 者】

：

Nan Ni Rui Zuo Weihao Zhuang Meijun Zhu Anastasios Kyriazoglou Duolin Wu Grant Eilers George D.Demetri Haibo Qiu Adrian Marino-Enriquez Jonathan A.Fletcher Wen-Bin Ou 

【机 构】

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Zhejiang Provincial Key Laboratory of Silkworm Bioreactor and Biomedicine,College of Life Sciences,Z

【出 处】

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中国生物化学与分子生物学会第十二届会员代表大会暨2018年全国学术会议

【发表日期】

：

2018年10期

【关键词】

：

cyclin D1 PRKCQ JUN KIT Hippo pathway gastrointestinal neoplasm 

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　　Purpose: Oncogenic KIT or PDGFRA tyrosine kinase mutations are compelling therapeutic targets in most gastrointestinal stromal tumors(GISTs),and the KIT/PDGFRA inhibitor,imatinib,is therefore standard of care for patients with metastatic GIST.

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