fat1转基因斑马鱼模型的建立和富含omega-3不饱和脂肪酸转基因鲤鱼的研制

来源 :第三届全国斑马鱼研究大会 | 被引量 : 0次 | 上传用户：maxiao912

【摘要】

：

　　脂肪酸在机体的能量提供和细胞膜构成等诸多方面发挥重要作用.其碳链上含有2个以上双键的脂肪酸被称作为多不饱和脂肪酸(Polyunsaturated fatty acids,PUFA),其中最为重

【作者】

：

庞少臣王厚鹏朱作言孙永华

【机构】

：

中国科学院水生生物研究所,淡水生态与生物技术国家重点实验室,武汉,430072;中国科学院大学,北京,100049中国科学院水生生物研究所,淡水生态与生物技术国家重点实验室,武汉,430072

【出处】

：

第三届全国斑马鱼研究大会

【发表日期】

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2013年10期

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　　脂肪酸在机体的能量提供和细胞膜构成等诸多方面发挥重要作用.其碳链上含有2个以上双键的脂肪酸被称作为多不饱和脂肪酸(Polyunsaturated fatty acids,PUFA),其中最为重要的PUFA 有omega-6 和omega-3 两大类.omega-3 PUFA,如EPA、DHA 等是人体重要的必需脂肪酸,被认为可以有效缓解心血管疾病,II 型糖尿病,抑制过激的炎症反应等.脊椎动物的基因组中缺乏delta-12 和omega-3 去饱和酶,无法从头合成EPA 和DHA 等omega-3 不饱和脂肪酸.因此,包括我们人类在内的脊椎动物需要从食物中摄取EPA 和DHA等omega-3 PUFA,以满足正常的生理和健康需求.深海鱼类是获取EPA、DHA 等omega-3PUFA 的主要来源.随着海洋渔业资源的萎缩,开发omega-3 PUFA 生产新途径的需求日渐迫切.

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fat1转基因斑马鱼模型的建立和富含omega-3不饱和脂肪酸转基因鲤鱼的研制

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