【摘 要】
：
目的:Apratoxin A是从海洋蓝藻中分离得到的一种具有强抗肿瘤活性的大环内酯肽类化合物.对人鼻咽癌KB细胞株和人结肠癌LoVo细胞株的IC50值分别为0.52 nM和0.36 nM.该化合物结构中包含了由四个天然氨基酸组成的四肽片段、新颖的α,β-不饱和半胱氨酸结构构成的手性噻唑啉环片段和含有四个手性中心的长链脂肪酸Dtena片段.
【机 构】
：
复旦大学药学院药化教研室,上海,201203
【出 处】
：
中国化学会第十届全国天然有机化学学术会议
论文部分内容阅读
目的:Apratoxin A是从海洋蓝藻中分离得到的一种具有强抗肿瘤活性的大环内酯肽类化合物.对人鼻咽癌KB细胞株和人结肠癌LoVo细胞株的IC50值分别为0.52 nM和0.36 nM.该化合物结构中包含了由四个天然氨基酸组成的四肽片段、新颖的α,β-不饱和半胱氨酸结构构成的手性噻唑啉环片段和含有四个手性中心的长链脂肪酸Dtena片段.
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