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  5. β2-adrenergic Signaling Modulates Excitation-contraction Coupling without Sensitizting Ryanodine Rec

β2-adrenergic Signaling Modulates Excitation-contraction Coupling without Sensitizting Ryanodine Rec

来源 :中国生理学会第24届全国会员代表大会暨生理学学术大会 | 被引量 : 0次 | 上传用户：w1352688
【摘 要】
：
β-Adrenergic receptor (βAR),mainly β1AR,mediates positive inotropy in heart.However,since β1AR induces severe arrhythmia in failing heart,it can not be used for clinical treatment.β2-adrenergic recept
【作 者】
：
Peng Zhou Hua-qian Yang Yan-Ting Zhao Ying-Ying Hu Shu-Hua Bai Xue-Mei Hao Shi-Qiang Wang 
【机 构】
：
State Key Laboratory of Biomembrane and Membrane Biotechnology,College of Life Sciences,Beijing 1008
【出 处】
：
中国生理学会第24届全国会员代表大会暨生理学学术大会
【发表日期】
：
2014年7期
【关键词】
：
β2-adrenergic receptor Ca2+signaling L-type Ca2+channel ryanodine receptor 
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　　β-Adrenergic receptor (βAR),mainly β1AR,mediates positive inotropy in heart.However,since β1AR induces severe arrhythmia in failing heart,it can not be used for clinical treatment.β2-adrenergic receptors (β2ARs) mediate a compartmental cAMP signaling uncoupled from cytosolic proteins,and regulate heart function mainly by enhancing L-type Ca2+ channel (LCC) currents.
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