石杉碱甲固体自徽乳的制备及评价

来源 :第二届全国生物颗粒学术研讨会、第三届国际工业药学和临床药学研讨会暨第一届岭南国际药学大会 | 被引量 : 0次 | 上传用户：a15968331849

【摘要】

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【作者】

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李芳胡容峰

【机构】

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安徽中医药大学,合肥 230038;省部共建新安医学教育部重点实验室,合肥 230038 省部共建

【出处】

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第二届全国生物颗粒学术研讨会、第三届国际工业药学和临床药学研讨会暨第一届岭南国际药学大会

【发表日期】

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2015年6期

【关键词】

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石杉碱甲球晶造粒技术固体自微乳粉体学性质体外释放度

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　　目的探讨球晶造粒技术制备石杉碱甲(Hup-A)固体自微乳.方法采用球晶造粒技术对Hup-A自微乳进行固化；运用粒径分析仪与透射电镜测定固化前后固体自微乳粒径、Zeta电位及微乳形态；考察粉体学性质；测定体外释放度.结果Hup-A固化前后自微乳的粒径及Zeta基本保持不变,平均粒径及Zeta电位为：(20.97±0.68) nm和(-19.4±0.52) mV,TEM下呈大小均匀的圆球形；固体自微乳为圆整球形,具有较好的流动性、可压性和填充性；1 h累积释放度约15.0％,24 h累积释放度达90.0％以上,释药行为符合Higuchi模型.结论球晶造粒技术可用于制备Hup-A固体自微乳.

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石杉碱甲固体自徽乳的制备及评价

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