Multiple sclerosis (MS) is an inflammatory-autoimmune disease of the central nervous system (CNS), leading to early axonal damage and neurodegeneration and lasting decades.The acute, focal phase of the disease is characterized by inflammation and acute damage of the myelin sheath and axons.At this stage, remyelination may be robust and efficient and early lesions of the white matter (fresh plaques) may be completely and correctly repaired and function restored.