Low-density lipoprotein-coupled N-succinyl chitosan lipoic acid micelles co-delivering siRNA and Pac

来源 :2015年中国药物制剂大会、中国药学会药剂专业委员会2015年学术年会暨国际控释协会中国分会2015年学术年会 | 被引量 : 0次 | 上传用户：hanfeizifly

【摘要】

：

【作者】

：

Shu-di Yang Xue-nong Zhang

【机构】

：

Department of Pharmaceutics, College of Pharmaceutical Science, Soochow University, Suzhou 215123,Pe

【出处】

：

2015年中国药物制剂大会、中国药学会药剂专业委员会2015年学术年会暨国际控释协会中国分会2015年学术年会

【发表日期】

：

2015年9期

【关键词】

：

low density lipoprotein siRNA paclitaxel micelles co-delivery tumor-targeting mu

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　　Objective: To increase targeting effect and reverse the multiple drug resistance(MDR) on cancer cells by building and investigating a pH and reducibility dual-sensitive "binary polymer" that Low density lipoprotein(LDL) was used as a targeting molecule as well as a vehicle of siRNA to coupled with N-succinyl chitosan lipoic acid micelles(NSC-LA) loaded with Paclitaxel(PTX).

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Low-density lipoprotein-coupled N-succinyl chitosan lipoic acid micelles co-delivering siRNA and Pac

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